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发表于 2020-3-22 13:00:46
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Ozone. Ozone has been used for years as a drinking water disinfectant. Ozone is produced when O2 is energized and split into two monatomic (O1) molecules. The monatomic oxygen molecules then collide with O2 molecules to form ozone, which is O3. Thus, ozone consists of O2 with a loosely bonded third oxygen atom that is readily available to attach to, and oxidize, other molecules. This additional oxygen atom makes ozone a powerful oxidant that destroys microorganisms but is highly unstable (i.e., half-life of 22 minutes at room temperature).
  臭氧。臭氧多年来一直被用作饮用水消毒剂。当O2通电并分裂为两个单原子（O1）分子时，会产生臭氧。然后，单原子的氧分子与O2分子碰撞形成臭氧，即O3。因此，臭氧由具有疏松键合的第三个氧原子的O2组成，该氧原子易于连接并氧化其他分子。这种额外的氧原子使臭氧成为一种强大的氧化剂，可以破坏微生物，但高度不稳定（即在室温下的半衰期为22分钟）。
A new sterilization process, which uses ozone as the sterilant, was cleared by FDA in August 2003 for processing reusable medical devices. The sterilizer creates its own sterilant internally from USP grade oxygen, steam-quality water and electricity; the sterilant is converted back to oxygen and water vapor at the end of the cycle by a passing through a catalyst before being exhausted into the room. The duration of the sterilization cycle is about 4 h and 15 m, and it occurs at 30-35°C. Microbial efficacy has been demonstrated by achieving a SAL of 10-6 with a variety of microorganisms to include the most resistant microorganism, Geobacillus stearothermophilus.
  FDA在2003年8月批准了使用臭氧作为灭菌剂的新灭菌工艺，用于处理可重复使用的医疗器械。灭菌器内部使用USP级氧气，蒸汽品质的水和电产生自己的灭菌剂；消毒剂在循环结束时通过排入房间之前先通过催化剂转化为氧气和水蒸气。灭菌周期的持续时间约为4 h和15 m，发生在30-35°C。微生物功效已通过多种微生物达到10-6的SAL来证明，其中包括最具抵抗力的微生物，嗜热脂肪地芽孢杆菌。
The ozone process is compatible with a wide range of commonly used materials including stainless steel, titanium, anodized aluminum, ceramic, glass, silica, PVC, Teflon, silicone, polypropylene, polyethylene and acrylic. In addition, rigid lumen devices of the following diameter and length can be processed: internal diameter (ID): > 2 mm, length ≤ 25 cm; ID > 3 mm, length ≤ 47 cm; and ID > 4 mm, length ≤ 60 cm.
  臭氧工艺与各种常用材料兼容，包括不锈钢，钛，阳极氧化铝，陶瓷，玻璃，二氧化硅，PVC，聚四氟乙烯，硅酮，聚丙烯，聚乙烯和丙烯酸。另外，也可以处理以下直径和长度的刚性管腔装置：内径（ID）：> 2 mm，长度≤25 cm；内径> 3毫米，长度≤47厘米;内径> 4毫米，长度≤60厘米。
The process should be safe for use by the operator because there is no handling of the sterilant, no toxic emissions, no residue to aerate, and low operating temperature means there is no danger of an accidental burn. The cycle is monitored using a self-contained biological indicator and a chemical indicator. The sterilization chamber is small, about 4 ft3 (Written communication, S Dufresne, July 2004).
  该过程应供操作人员安全使用，因为无需处理消毒剂，没有毒性排放物，无残留物，且工作温度低意味着不存在意外燃烧的危险。使用自含式生物指示剂和化学指示剂监测循环。灭菌室很小，大约4立方英尺（书面通讯，S Dufresne，2004年7月）。
A gaseous ozone generator was investigated for decontamination of rooms used to house patients colonized with MRSA. The results demonstrated that the device tested would be inadequate for the decontamination of a hospital room946.
  研究了一种气态臭氧发生器用于消毒被耐甲氧西林金黄色葡萄球菌（MRSA）污染的病房。结果表明，所测试的设备不足以对946号医院房间进行消毒。
——摘自CDC Guideline for Disinfection and Sterilization in Healthcare Facilities (2008) |
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