超温报警啦之 ③ 速冻水饺？

歪说歪有李

某天，在即将换老板的商店，买打折的速冻水饺。
忽然想，这个饺子是冻干机做出来的？后来一想，不可能，大炮打蚊子。
但是，当你把几大瓶制备好的培养基放冷藏箱冷藏时，你考虑过冷藏箱的感受吗？
臣妾做不到啊。所以，你不报警谁报警？

The evaporator defrost generally occursby redirecting the hot refrigerant gas into the evaporator coil for a short time to melt ice/frost accumulation.Depending on the manufacturer and model, the defrost cycle is terminated by:

蒸发器除霜通常是通过将热制冷剂气体重新定向到蒸发器盘管中，在短时间内融化积冰/霜来实现的。根据制造商和型号的不同，除霜周期以以下方式结束:

•         Elapsed time  运行时间

•         Evaporator coil temperature set point 蒸发器盘管温度设定点

•         A combination of time and temperature 时间和温度的组合

The timeddefrost is adjustable to allow for the conditions of use (frequency of door opening,length of time for door opening, and exterior air humidity level at time of door opening), with the preference to have the defrost cycle occuroutside of normal working hours. The defrost cycle can usually be adjusted.

定时除霜可根据使用条件(开门频率、开门时间长度和开门时的外部空气湿度水平)进行调节，最好在正常工作时间之外进行除霜。除霜周期通常可以调整。

Models with manual defrostare also available. The temperature uniformity in time offeredby the two systems could be different.

也有手动除霜的型号。两种系统提供的时间温度均匀性可能不同。

The defrostcycle can also be initiatedby a low suction pressure/super heating of the compressor.

除霜循环也可以通过压缩机的低吸入压力/过热来启动。

Theseaspects relevant to defrosting apply also to equipment such as refrigeratorsand freezers.

与除霜相关的这些方面也适用于冷藏箱和冰箱等设备。

For GMP applications thesesystems should be monitored. It can be difficult to calibrate the system controlsensor, and the use of an independent system allows routine calibrationand the flexibility to place the sensor in a location that measures theworst-case temperature. Location is determined from test results (see Section5.4).

对于GMP场景，这些系统应该被监控。校准系统控制传感器可能很困难，使用独立的系统可以进行常规校准，并且可以灵活地将传感器放置在测量最差情况温度的位置。该位置由测试结果确定(见第5.4节)。

Remote connections could also bewireless.

远程连接也可以是无线的。

Backup cooling systemsusing liquid nitrogenor carbon dioxide(CO2) are available and could be included, if necessary, to increase the reliability of operation and mitigate temperature excursions during power failures.

使用液氮或二氧化碳(CO2)的备用冷却系统是可用的，如果有必要，可以应用以提高运行的可靠性并减轻电力故障期间的温度偏差。

1.1.1          Conditioning/Blast Freezers 程序/速冷冰箱

Facilitiesmay process large quantities of bulk product that need to be frozen fromambient conditions to a specified temperature, e.g., -70℃, prior to transfer into a -70℃ storage unit. Dedicated conditioning freezers are neededto perform this function, as storage freezers are not capable of handling thelarge volume of product and significant temperature disparity without potentially compromising the temperature of the storedmaterial. This type of equipment is outside the scope of thisGuide.

一些产品需要在转移到-70℃的存储箱体之前，从环境条件冷冻到指定的温度，例如-70℃，这种设施可以大量处理这类散装产品。需要专用的程序冰箱来执行此功能，因为存储用冰箱无法在不影响存储材料温度的情况下处理大量产品和显著的温度差异。这种类型的设备不在本指南的范围之内。

1.1.2          Liquid NitrogenFreezers 液氮冰箱

Liquidnitrogen freezers are used for storing material below -120℃, for example, cell banks. If materials are immersed into liquid nitrogen, they eventually assumethe temperature of the liquid(-196℃). Materials stored in the vapor above the liquid become warmeras they are moved away from the liquid (up to -120℃).

液氮用于储存-120℃以下的物质，例如细胞库。如果材料浸入液氮中，它们最终会达到液氮的温度(-196℃)。储存在液体上方蒸汽中的材料在远离液体时变得更热(高达-120℃)。

Itis thus important to define the purpose of the equipment. In the case ofcryopreservation of animal cells or tissues, the required temperature will be lowerthan the glasstransition temperature of water, that is, -130℃. The temperature of the vapor can be changedby varying the amount of liquid nitrogen in the chamber.

因此，确定设备的用途是很重要的。在低温保存动物细胞或组织的情况下，所需温度将低于水的玻璃化转变温度，即-130℃。蒸汽的温度可以通过改变腔室中液氮的量来改变。

xqliu

学习了，谢谢提供分享。