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[GMP相关] Technical Requirements of a RO System

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药士
发表于 2016-12-16 22:27:44 | 显示全部楼层 |阅读模式

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选自:http://www.fda.gov/ICECI/Inspections/InspectionGuides/InspectionTechnicalGuides/ucm072913.htm
Technical Requirements of a RO System
Several basic technical requirements of a RO system are:
  • Feed water should be adjusted to proper pH and be prefiltered. The amount of TDS and suspended materials in the feed water after prefiltration should be controlled within the designed limits.(实际上很少有人在前期RO对TDS进行直接测定,最多也仅仅是硬度
  • Feed water and product water should be monitored for microbiological quality. The system should be disinfected when microbiological quality levels are exceeded.(有好多企业针对于前面的ACF或者softener过滤水进行过定期微生物检测呢??
  • All system components should be mechanically cleaned before disinfecting. Appropriate tests should be performed to assure that chemicals used in disinfection are completely removed from the system.
  • The use of filters or ion-exchangers down stream of RO modules should be avoided.(为什么要避免ion-exchangers???EDI不是经常在RO配套吗?
  • The RO system should be designed for continuous flow without traps, dead ends and pipe sections which may collect stagnant water.
  • The chemical and microbial quality of water should be tested at predetermined intervals during a production cycle. In-line conductivity probes should be installed at key points for continuous monitoring of water quality.
  • The equipment should be qualified and the RO system should be validated periodically, as well as operated and maintained according to manufacturer's instructions so that it can consistently produce water with acceptable quality.

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药士
 楼主| 发表于 2016-12-16 22:29:30 | 显示全部楼层
同时请教一个问题,为什么RO前面的增压泵后侧压力会小于RO浓水压力呢??非常感谢!
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药徒
发表于 2016-12-16 23:13:25 | 显示全部楼层
我一直在观察楼主的帖子,发过很多问题,不知道最后解决好了没有?
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药神
发表于 2023-2-23 20:48:51 | 显示全部楼层
感谢分享。
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