http://www.nature.com/ki/journal/v59/n6/full/4492263a.html

0.1mg/kg体重

Methods

Female New Zealand White rabbits were injected intraperitoneally with either 0.1 mg AA/kg or with saline 5 days a week for 17 to 21 months. Body weight, renal function, and urinary excretion of glucose and low molecular weight proteins were monitored prior to sacrifice at the end of the study period.

0.1mg/kg体重/天，连续五天（这个量是临床常用摄取量的6倍）17~21个月，发现兔子有生理变化，控制组有两个肿瘤，从三个月开始，有些检测指标开始和对照组不同。